ABSTRACT
A 22-year-old woman was referred to our emergency department for the treatment of a chemical injury on her arm. She had accidentally spilled 99% trifluoroacetic anhydride (TFAA) over her left forearm during an organic chemistry experiment. She visited a primary care unit, and then she was referred to our hospital for inactivation of the released fluoride ions. Her skin lesions were different from those caused by hydrofluoric acid (HF) injury. The injured area showed painful whitish maculae and patchy areas with accentuated rim. No vesiculation and bulla formation was detected. We intradermally injected a 5% solution of calcium through a 24-gauge needle into the burned skin. After the injection, she complained of more severe pain. Although TFAA contains fluorine, it does not release free fluoride ions on contact with the skin, unlike HF. In fact, application of calcium gluconate for TFAA burns is not recommended. Rather, it should be avoided since it increases pain and local abscess formation.
Subject(s)
Female , Humans , Young Adult , Abscess , Acetic Anhydrides , Arm , Blister , Burns , Burns, Chemical , Calcium , Calcium Gluconate , Chemistry, Organic , Emergencies , Fluorides , Fluorine , Fluoroacetates , Forearm , Gluconates , Hydrofluoric Acid , Ions , Needles , Primary Health Care , Skin , Trifluoroacetic AcidABSTRACT
Dicloridrato de cetirizina, novo anti-histamínico H1, foi doseado volumetricamente em meio anidro com ácido perclórico e por espectrofotometria, em 232 nm. Verificou-se que ambos os métodos säo viáveis e precisos, sendo o doseamento em meio näo-aquoso mais prático por näo requerer instrumental e ser mais rápido e fácil de executar.
Subject(s)
Drug Evaluation/methods , Cetirizine/chemistry , Acetic Acid/administration & dosage , Hydrochloric Acid/administration & dosage , Acetic Anhydrides/administration & dosage , Laboratory Chemicals , Perchlorates/administration & dosage , Quinaldines/administration & dosage , Spectrophotometry, UltravioletABSTRACT
The structure of a compound [compd. Z] obtained from the reaction of 4-amino-3-carbamoyl-5-ethoxycarbonylisothiazole of 4-amino-3-carbamoyl-5-ethoxycarbonylisothiazole [I] with formamide/acetic anhydride mixture has been investigated on the ground of microanalytical and spectral data, and chemical evidences. A mechanism for the reaction of this compound with hydrazine hydrate to give 4-amino-3,5-dihydrazinocarbonylisothiazole has been proposed. The preparation of certain 4-amino-3,5- diarylidenehydrazinocarbonylisothiazoles [VIIa-j] was described